Alan R. Clarke

Independent Researcher

0000-0002-4281-426X

384

Publications

23,577

Citations

H-Index

199

i10-Index

0.25

2yr Mean Cite

Cite/Paper

Data combined from OpenAlex + Semantic Scholar. OA = OpenAlex S2 = Semantic Scholar

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Publication & Citation Trends

Most Cited Works

Thymocyte apoptosis induced by p53-dependent and independent pathways

Alan R. Clarke, Colin A. Purdie, David J. Harrison, Russell E. Morris, C C Bird +2 more

Nature 1993

2,291

Crypt stem cells as the cells-of-origin of intestinal cancer

Nick Barker, Rachel A. Ridgway, Johan H. van Es, Marc van de Wetering, Harry Begthel +5 more

Nature 2008

2,142

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

Peter Mombaerts, Alan R. Clarke, Michael A. Rudnicki, John Iacomini, Shigeyoshi Itohara +6 more

Nature 1992

1,115

Requirement for a functional Rb-1 gene in murine development

Alan R. Clarke, Els Robanus Maandag, M van Roon, Nathalie M. T. van der Lugt, Martin van der Valk +3 more

Nature 1992

1,007

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration OA

Owen J. Sansom, Karen R. Reed, Anthony J. Hayes, Heather Ireland, Hannah Brinkmann +7 more

Genes & Development 2004

794

Publications

384 total

Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium OA

C. Daly, P. Shaw, L. D. Ordonez, G. T. Williams, J. Quist - Oncogene, 2024

Cited by 0 Semantic Scholar

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling OA

Inma M. Berenjeno, R. Piñeiro, Sandra D. Castillo, Wayne Pearce, N. Mcgranahan - Nature Communications, 2017

Cited by 6 Semantic Scholar

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium OA

C. Daly, P. Shaw, L. D. Ordonez, G. T. Williams, J. Quist - Oncogene, 2016

Cited by 28 Semantic Scholar

Hepatic progenitor cells of biliary origin with liver repopulation capacity PDF

Wei‐Yu Lu, Thomas G. Bird, Luke Boulter, Atsunori Tsuchiya, Alicia M. Cole et al. - Nature Cell Biology, 2015

Cited by 497 OpenAlex

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo OA

T. Phesse, K. Myant, Alicia M. Cole, Rachel A. Ridgway, Helen B. Pearson - Cell Death and Differentiation, 2014

Cited by 96 Semantic Scholar

Manipulation of liver regeneration with macrophages to influence the hepatic progenitor cell niche OA

Thomas G. Bird, L. Boutler, Alicia M. Cole, S. Lorenzini, Wei Lu - Unknown Venue, 2013

Cited by 4 Semantic Scholar

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

A. Hammoudi, Fei Song, K. Reed, R. Jenkins, V. Meniel - Biochemical and Biophysical Research Communications - BBRC, 2013

Cited by 33 Semantic Scholar

Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apcmin/+ mouse OA

Paul Shaw, Tim Maughan, A. Clarke - British Journal of Cancer, 2011

Cited by 11 Semantic Scholar

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival OA

James Matthews, Owen J. Sansom, A. Clarke - Cell Death and Differentiation, 2011

Cited by 61 Semantic Scholar

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. OA

G. H. Ashton, J. Morton, K. Myant, T. Phesse, Rachel A. Ridgway - Developmental Cell, 2010

Cited by 36 Semantic Scholar

Research Topics

Cancer-related Molecular Pathways (73) Wnt/β-catenin signaling in development and cancer (45) Genetic factors in colorectal cancer (42) Cancer-related gene regulation (30) Cancer Cells and Metastasis (28)

Frequent Co-Authors

Owen J. Sansom

6 joint publications

Martin Hooper

4 joint publications

Hans Clevers

3 joint publications

David J. Harrison

2 joint publications

M.L. Hooper

2 joint publications

Rachel A. Ridgway

2 joint publications

Affiliations

Royal Society

GB 1996 - 1996

University of Leeds

GB 2002 - 2002

Howard Hughes Medical Institute

US 1991 - 1991

Harvard University

US 2023 - 2023

iRobot (United States)

US 1997 - 1997

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Alan R. Clarke

Publication & Citation Trends

Most Cited Works

Publications

Correction: Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium OA

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling OA

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium OA

Hepatic progenitor cells of biliary origin with liver repopulation capacity PDF

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo OA

Manipulation of liver regeneration with macrophages to influence the hepatic progenitor cell niche OA

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apcmin/+ mouse OA

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival OA

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. OA

Research Topics

Frequent Co-Authors

Affiliations

External Profiles

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