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GH

Guus J.J.E. Heynen

Charité - Universitätsmedizin Berlin DE

ORCID 0000-0001-7721-5710
67
Publications
2,060
Citations
14
H-Index
15
i10-Index
0
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex . OA = OpenAlex S2 = Semantic Scholar
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Publication & Citation Trends

Most Cited Works

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma OA
Chong Sun, Liqin Wang, Sidong Huang, Guus J.J.E. Heynen, Anirudh Prahallad +20 more
Nature 2014
902
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase
Dietrich Alexander Ruess, Guus J.J.E. Heynen, Katrin J. Ciecielski, Jiaoyu Ai, Alexandra Berninger +21 more
Nature Medicine 2018
365
Reduced <i>NF1</i> Expression Confers Resistance to EGFR Inhibition in Lung Cancer OA
Elza C. de Bruin, Catherine Cowell, Patricia H. Warne, Ming Jiang, Rebecca E. Saunders +15 more
Cancer Discovery 2014
208
PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs OA
Anirudh Prahallad, Guus J.J.E. Heynen, Giovanni Germano, Stefan M. Willems, Bastiaan Evers +7 more
Cell Reports 2015
176
Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors
Giovanni Valenti, Hazel M. Quinn, Guus J.J.E. Heynen, Linxiang Lan, Jane D. Holland +3 more
Cancer Research 2017
170

Publications

67 total

SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma PDF

Guus J.J.E. Heynen, Francis Baumgartner, Michael Heider, Upayan Patra, Maximilian Holz et al. - Blood Advances, 2022
Cited by 31 OpenAlex

Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors PDF

Guus J.J.E. Heynen, Kamil Lisek, Regina Vogel, Annika Wulf-Goldenberg, Joshua Alcaniz et al. - Breast Cancer Research, 2022
Cited by 17 OpenAlex

From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement PDF

Yelena Mostinski, Guus J.J.E. Heynen, María P. López‐Alberca, Jérôme Paul, Sandra Miksche et al. - Journal of Medicinal Chemistry, 2020
Cited by 25 OpenAlex

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Dietrich Alexander Ruess, Guus J.J.E. Heynen, Katrin J. Ciecielski, Jiaoyu Ai, Alexandra Berninger et al. - Nature Medicine, 2018
Cited by 365 OpenAlex

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase

Dietrich Alexander Ruess, Guus J.J.E. Heynen, Katrin J. Ciecielski, Walter Birchmeier, Roland M. Schmid et al. - Pancreatology, 2018
Cited by 18 OpenAlex

Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors

Giovanni Valenti, Hazel M. Quinn, Guus J.J.E. Heynen, Linxiang Lan, Jane D. Holland et al. - Cancer Research, 2017
Cited by 170 OpenAlex

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer PDF

Hongde Li, William Stokes, Emily Chater, Rajat Roy, Elza de Bruin et al. - Cell Discovery, 2016
Cited by 37 OpenAlex

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma

Guus J.J.E. Heynen, Ekaterina Nevedomskaya, Sander Palit, Noorjahan Jagalur Basheer, Cor Lieftink et al. - Molecular Cancer Research, 2016
Cited by 23 OpenAlex

PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs PDF

Anirudh Prahallad, Guus J.J.E. Heynen, Giovanni Germano, Stefan M. Willems, Bastiaan Evers et al. - Cell Reports, 2015
Cited by 176 OpenAlex

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor PDF

Elena Galvani, Jing Sun, Leticia G. León, Rocco Sciarrillo, Ravi S. Narayan et al. - Oncotarget, 2015
Cited by 31 OpenAlex

Research Topics

Neuroblastoma Research and Treatments (17) Lung Cancer Treatments and Mutations (14) Cancer Mechanisms and Therapy (14) Epigenetics and DNA Methylation (11) Hedgehog Signaling Pathway Studies (11)

Frequent Co-Authors

RE
René Bernards
7 joint publications
WA
Walter Birchmeier
5 joint publications
PR
Prashanth Kumar Bajpe
3 joint publications
CO
Cor Lieftink
3 joint publications
RO
Roderick L. Beijersbergen
3 joint publications
EG
Egbert F. Smit
3 joint publications

Affiliations

Memorial Sloan Kettering Cancer Center
US 2014 - 2014
Institute of Cancer Research
GB 2014 - 2014
German Cancer Research Center
DE 2022 - 2022
Max Delbrück Center
DE 2022 - 2017
Heidelberg University
DE 2022 - 2022

External Profiles

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