P. Brian Smith
0000-0002-9330-3048
Publication & Citation Trends
Most Cited Works
Publications
69 total
Abstract B002: Structural and functional analysis of the resistance mechanisms of KRAS-G12C secondary mutations to switch-II pocket inhibitors
Cited by 0
Semantic Scholar
Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants.
Cited by 0
Semantic Scholar
Abstract A047: KRAS G12C and G12D mutants exhibit distinct conformational flexibility in the helix 3–switch 2 pocket that drives differential protein function
Cited by 0
Semantic Scholar
Abstract 7104: BBO-11818: An orally bioavailable, highly potent and selective non-covalent pan-KRAS(ON) and (OFF) inhibitor with robust anti-tumor activity in KRAS-mutant preclinical models
Cited by 0
Semantic Scholar
Abstract C082: BBO-10203, a first-in-class, orally bioavailable, selective breaker of the RAS:PI3Kα interaction inhibits tumor growth alone and in combination with KRAS inhibitors in KRAS mutant models without inducing hyperglycemia
Cited by 0
Semantic Scholar
Abstract PS7-04: BBO-10203, a first-in-class, orally bioavailable, selective blocker of the PI3Kα:RAS interaction inhibits tumor growth alone and in combination with standard of care therapies in breast cancer models without inducing hyperglycemia
Cited by 1
Semantic Scholar
Abstract 4378: BBO-11818, an orally bioavailable, highly potent and non-covalent pan-KRAS inhibitor demonstrates robust anti-tumor activity in KRAS-mutant preclinical models
Cited by 2
Semantic Scholar
Abstract 3788: BBO-8520, a first-in-class direct dual inhibitor of GTP-bound (ON) and GDP-bound (OFF) KRASG12C, exhibits robust efficacy in non-small cell lung cancer preclinical models
Cited by 0
Semantic Scholar
Research Topics
Neonatal Respiratory Health Research
(13)
Neonatal and Maternal Infections
(11)
Prenatal Substance Exposure Effects
(7)
Neonatal Health and Biochemistry
(7)
Infant Development and Preterm Care
(6)
Frequent Co-Authors
Affiliations
Health Canada
Illinois Department of Public Health
Duke University
Great Ormond Street Hospital for Children NHS Foundation Trust
North Cumbria Integrated Care NHS Foundation Trust