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KC

Katleen Craessaerts

Vlaams Instituut voor Biotechnologie BE

ORCID 0000-0001-6684-8475
72
Publications
11,294
Citations
33
H-Index
40
i10-Index
6.86
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex . OA = OpenAlex S2 = Semantic Scholar
Verify on Google Scholar

Publication & Citation Trends

Most Cited Works

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain
Bart De Strooper, Wim Annaert, Philippe Cupers, Paul Säftig, Katleen Craessaerts +7 more
Nature 1999
2,093
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
Bart De Strooper, Paul Säftig, Katleen Craessaerts, Hugo Vanderstichele, Gundula Guhde +3 more
Nature 1998
1,812
Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease OA
Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio +18 more
Cell 2020
921
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling OA
Sara Cipolat, Tomasz Rudka, Dieter Hartmann, Veronica Costa, Lutgarde Serneels +11 more
Cell 2006
730
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency OA
An Herreman, Dieter Hartmann, Wim Annaert, Paul Säftig, Katleen Craessaerts +12 more
Proceedings of the National Academy of Sciences 1999
521

Publications

72 total

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease PDF

Sriram Balusu, Katrien Horré, Nicola Thrupp, Katleen Craessaerts, An Snellinx et al. - Science, 2023
Cited by 202 OpenAlex

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease PDF

Wei-Ting Chen, Ashley Lu, Katleen Craessaerts, Benjamin Pavie, Carlo Sala Frigerio et al. - Cell, 2020
Cited by 921 OpenAlex

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

Vanessa A. Morais, Dominik Haddad, Katleen Craessaerts, Pieter‐Jan De Bock, Jef Swerts et al. - Science, 2014
Cited by 363 OpenAlex

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex PDF

Ellen Jorissen, Johannes Prox, Christian Bernreuther, Silvio Weber, Ralf Schwanbeck et al. - Journal of Neuroscience, 2010
Cited by 355 OpenAlex

γ-Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer’s Disease PDF

Lutgarde Serneels, Jérôme Van Biervliet, Katleen Craessaerts, Tim Dejaegere, Katrien Horré et al. - Science, 2009
Cited by 258 OpenAlex

Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling PDF

Sara Cipolat, Tomasz Rudka, Dieter Hartmann, Veronica Costa, Lutgarde Serneels et al. - Cell, 2006
Cited by 730 OpenAlex

Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice PDF

Diana Dominguez, Jos Tournoy, Dieter Hartmann, Tobias Huth, Kim Cryns et al. - Journal of Biological Chemistry, 2005
Cited by 351 OpenAlex

Neuronal membrane cholesterol loss enhances amyloid peptide generation PDF

José Abad‐Rodríguez, María Dolores Ledesma, Katleen Craessaerts, Simona Perga, Miguel Medina et al. - The Journal of Cell Biology, 2004
Cited by 335 OpenAlex

γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

An Herreman, Geert Van Gassen, Mustapha Bentahir, Omar Nyabi, Katleen Craessaerts et al. - Journal of Cell Science, 2003
Cited by 195 OpenAlex

The amyloid precursor protein (APP)‐cytoplasmic fragment generated by γ‐secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

Philippe Cupers, Isabelle Orlans, Katleen Craessaerts, Wim Annaert, Bart De Strooper - Journal of Neurochemistry, 2001
Cited by 229 OpenAlex

Research Topics

Alzheimer's disease research and treatments (42) Neuroinflammation and Neurodegeneration Mechanisms (11) Neuroscience and Neuropharmacology Research (8) Nuclear Receptors and Signaling (8) Mitochondrial Function and Pathology (6)

Frequent Co-Authors

BA
Bart De Strooper
15 joint publications
WI
Wim Annaert
7 joint publications
LU
Lutgarde Serneels
6 joint publications
PA
Paul Säftig
5 joint publications
PH
Philippe Cupers
3 joint publications
AN
An Snellinx
3 joint publications

Affiliations

Allen Institute for Brain Science
US 2023 - 2023
Radboud University Nijmegen
NL 2005 - 2005
Heidelberg University
DE 2001 - 2001
Vlaams Instituut voor Biotechnologie
BE 2025 - 1998
VIB-KU Leuven Center for Cancer Biology
BE 2020 - 2008

External Profiles

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