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Genetic studies of body mass index yield new insights for obesity biology

The LifeLines Cohort Study, Adam E. Locke, The AGEN-BMI Working Group, The GLGC, The ICBP, The MAGIC Investigators, Bratati Kahali, Sonja I. Berndt, Anne E. Justice, Tune H. Pers, Felix R. Day, C. E. Powell, Sailaja Vedantam, Martin L. Buchkovich, Jian Yang, Damien C. Croteau‐Chonka, Tõnu Esko, Tove Fall, Teresa Ferreira, Stefan Gustafsson, Zoltán Kutalik, Jian’an Luan, Reedik Mägi, Joshua C. Randall, Thomas W. Winkler, Andrew R. Wood, Tsegaselassie Workalemahu, Jessica D. Faul, Jennifer A. Smith, Wei Zhao, Wei Zhao, Ming‐Huei Chen, Rudolf S.N. Fehrmann, Åsa K. Hedman, Juha Karjalainen, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bolton, Jennifer L. Bragg‐Gresham, Steven Buyske, Ayşe Demirkan, Guohong Deng, Georg Ehret, Bjarke Feenstra, Mary F. Feitosa, Krista Fischer, Anuj Goel, Jian Gong, Anne Jackson, Stavroula Kanoni, Marcus E. Kleber, Kati Kristiansson, Unhee Lim, Vaneet Lotay, Massimo Mangino, Irene Mateo Leach, Carolina Medina‐Gómez, Sarah E. Medland, Michael A. Nalls, Lyle J. Palmer, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Dmitry Shungin, Alena Stančáková, Rona J. Strawbridge, Yan V. Sun, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Jessica van Setten, Jana V. van Vliet‐Ostaptchouk, Thomas J. Wang, Loïc Yengo, Weihua Zhang, Aaron Isaacs, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Antony Attwood, Stefania Bandinelli, Amy Barrett, Isabelita Bas, Claire Bellis, Amanda J. Bennett, Christian Berne, Roza Blagieva, Matthias Blüher, Stefan Böhringer, Lori L. Bonnycastle, Yvonne Böttcher, Heather A. Boyd, Marcel Bruinenberg, Ida Henriette Caspersen, Yii‐Der Ida Chen, Robert Clarke, E. Warwick Daw, Anton J. M. de Craen, Graciela Delgado, Maria Dimitriou, Alex S. F. Doney, Niina Eklund, Karol Estrada, Elodie Eury, Lasse Folkersen, Ross M. Fraser, Melissa E. Garcia, Frank Geller, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Alison H. Goodall, Scott D. Gordon, Mathias Gorski, Hans J. Grabe, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Henrik Grönberg, Christopher J. Groves, Gaëlle Gusto, Jeffrey Haessler, Per Hall, Toomas Haller, Göran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Nancy L. Heard‐Costa, Quinta Helmer, Christian Hengstenberg, Oddgeir L. Holmen, Jouke‐Jan Hottenga, Anthony James, Janina M. Jeff, Åsa Johansson, Jennifer Jolley, Thorhildur Juliusdottir, Leena Kinnunen, Wolfgang Köenig, Markku Koskenvuo, Wolfgang Kratzer, Jaana Laitinen, Claudia Lamina, Karin Leander, Sang Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Ken Sin Lo, Stéphane Lobbens, Roberto Lorbeer, Yingchang Lu, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Stela McLachlan, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Alireza Moayyeri, Keri L. Monda, Mario A. Morken, Antonella Mulas, Gabriele Müller, Martina Müller‐Nurasyid, Arthur W. Musk, Ramaiah Nagaraja, Markus M. Nöthen, Ilja M. Nolte, Stefan Pilz, Nigel W. Rayner, Frida Renström, Rainer Rettig, Janina S. Ried, Stephan Ripke, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Fredrick R. Schumacher, William R. Scott, Thomas Seufferlein, Jianxin Shi, Albert V. Smith, Joanna Smolonska, Alice Stanton, Valgerður Steinthórsdóttir, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann‐Christine Syvänen, Han Sun, Bamidele O. Tayo, Barbara Thorand, Guðmar Þorleifsson, Jonathan P. Tyrer, Hae‐Won Uh, Liesbeth Vandenput, Frank C. Verhulst, Sita H. Vermeulen, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Helen R. Warren, Dawn Waterworth, Michael N. Weedon, Lynne R. Wilkens, Christina Willenborg, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Alan F. Wright, Qunyuan Zhang, Eoin Brennan, Murim Choi, Zari Dastani, Alexander Drong, Per Eriksson, Anders Franco-Cereceda, Jesper R. Gådin, Ali G. Gharavi, Michael E. Goddard, Robert E. Handsaker, Jinyan Huang, Fredrik Karpe, Sekar Kathiresan, Sarah Keildson, Krzysztof Kiryluk, Michiaki Kubo, Jong‐Young Lee, Liming Liang, Richard P. Lifton, Baoshan Ma, Steven A. McCarroll, Amy Jayne McKnight, Josine L. Min, Miriam F. Moffatt, Grant W. Montgomery, Joanne M. Murabito, Geoffrey C. Nicholson, Dale R. Nyholt, Yukinori Okada, John R. B. Perry, Rajkumar Dorajoo, Eva Reinmaa, Rany M. Salem, Niina Sandholm, Robert A. Scott, Lisette Stolk, Atsushi Takahashi, Toshihiro Tanaka, Ferdinand M. van’t Hooft, Anna A. E. Vinkhuyzen, Harm-Jan Westra, Wei Zheng, Krina T. Zondervan, Andrew C. Heath, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, John Blangero, Pascal Bovet, Harry Campbell, Mark J. Caulfield, G Cesana, Aravinda Chakravarti, Daniel I. Chasman, Peter S. Chines, Francis S. Collins, Dana C. Crawford, L. Adrienne Cupples, Daniele Cusi, John Danesh, Ulf dé Fairé, Hester M. den Ruijter, Anna F. Dominiczak, Raimund Erbel, Jeanette Erdmann, Johan G. Eriksson, Martin Farrall, Stephan B. Felix, Ele Ferrannini, Jean Ferrières, Ian Ford, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Ron T. Gansevoort, Pablo V. Gejman, Christian Gieger, Omri Gottesman, Vilmundur Guðnason, Ulf Gyllensten, Alistair S. Hall, Tamara B. Harris, Andrew T. Hattersley, Andrew A. Hicks, Lucia A. Hindorff, Aroon D. Hingorani, Albert Hofman, Georg Homuth, G. Kees Hovingh, Steve E. Humphries, Steven C. Hunt, Elina Hyppönen, Thomas Illig, Kevin B. Jacobs, Marjo‐Riitta Järvelin, Karl‐Heinz Jöckel, Berit Johansen, Pekka Jousilahti, J. Wouter Jukema, Antti Jula, Jaakko Kaprio, John J.P. Kastelein, Sirkka Keinänen‐Kiukaanniemi, Lambertus A. Kiemeney, Paul Knekt, Jaspal S. Kooner, Charles Kooperberg, Péter Kovács, Aldi T. Kraja, Meena Kumari, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg, Loı̈c Le Marchand, Terho Lehtimäki, Valeriya Lyssenko, Satu Männistö, André Marette, Tara C. Matise, Colin A. McKenzie, Barbara McKnight, Frans L. Moll, Andrew D. Morris, Andrew P. Morris, Jeffrey C. Murray, Mari Nelis, Claes Ohlsson, Albertine J. Oldehinkel, Ken K. Ong, Pamela A. F. Madden, Gerard Pasterkamp, John F. Peden, Annette Peters, Dirkje S. Postma, Peter P. Pramstaller, Jackie F. Price, Lu Qi, Olli Raitakari, Tuomo Rankinen, D. C. Rao, Treva Rice, Paul M. Ridker, John D. Rioux, Marylyn D. Ritchie, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Jouko Saramies, Mark A. Sarzynski, Heribert Schunkert, Peter Schwarz, Peter Sever, Alan R. Shuldiner, Juha Sinisalo, Ronald P. Stolk, Konstantin Strauch, Anke Tönjes, David‐Alexandre Trégouët, Angelo Tremblay, Elena Tremoli, Jarmo Virtamo, Marie‐Claude Vohl, Uwe Völker, Gérard Waeber, Gonneke Willemsen, Jacqueline C.M. Witteman, M. Carola Zillikens, Linda S. Adair, Philippe Amouyel, Folkert W. Asselbergs, Themistocles L. Assimes, Murielle Bochud, Bernhard O. Boehm, Eric Boerwinkle, Stefan R. Bornstein, Erwin P. Böttinger, Claude Bouchard, Stéphane Cauchi, John C. Chambers, Stephen J. Chanock, Stephen S. Rich, Paul I. W. de Bakker, George Dedoussis, Luigi Ferrucci, Paul W. Franks, Philippe Froguel, Per‐Henrik Groop, Christopher A. Haiman, Anders Hamsten, Jennie Hui, David J. Hunter, Kristian Hveem, Robert C. Kaplan, Mika Kivimäki, Diana Kuh, Markku Laakso, Ching‐Ti Liu, Nicholas G. Martin, Winfried März, Mads Melbye, Andres Metspalu, Susanne Moebus, Patricia B. Munroe, Inger Njølstad, Ben A. Oostra, Colin N. A. Palmer, Nancy L. Pedersen, Markus Perola, Louis Përusse, Ulrike Peters, Chris Power, Thomas Quertermous, Rainer Rauramaa, Fernando Rivadeneira, Timo Saaristo, Danish Saleheen, Naveed Sattar, Eric E. Schadt, David Schlessinger, P. Eline Slagboom, Harold Snieder, Tim D. Spector, Unnur Þorsteinsdóttir, Michael Stümvoll, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Mark Walker, Henri Wallaschofski, Nicholas J. Wareham, Hugh Watkins, David R. Weir, H‐Erich Wichmann, James F. Wilson, Pieter Zanen, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Iris M. Heid, Jeffrey R. O’Connell, David P. Strachan, Kāri Stefánsson, Cornelia M. van Duijn, Gonçalo R. Abecasis, Lude Franke, Timothy M. Frayling, Mark I. McCarthy, Peter M. Visscher, André Scherag, Cristen J. Willer, Michael Boehnke, Karen L. Mohlke, Cecilia M. Lindgren, J. Beckmann, Inês Barroso, Kari E. North, Erik Ingelsson, Joel N. Hirschhorn, Ruth J. F. Loos, Elizabeth K. Speliotes

Nature, 2015

University of Michigan, National Institutes of Health, National Cancer Institute, University of North Carolina at Chapel Hill, Broad Institute, Boston Children's Hospital, Harvard University, Massachusetts Institute of Technology, Technical University of Denmark, University of Cambridge, MRC Epidemiology Unit, Michigan Medicine, The University of Queensland, Uppsala University, Science for Life Laboratory, Karolinska Institutet, Centre for Human Genetics, University of Oxford, Translational Research Institute, Brigham and Women's Hospital, University Hospital of Lausanne, Institute of Social and Preventive Medicine, University of Tartu, University of Regensburg, SIB Swiss Institute of Bioinformatics, University of Exeter, University of Lausanne, Wellcome Sanger Institute, University Medical Center Groningen, University of Groningen, Institute for Social Research, HudsonAlpha Institute for Biotechnology, Erasmus MC, The Kids Research Institute Australia, The University of Western Australia, Leiden University Medical Center, Netherlands Consortium for Healthy Ageing, University of Edinburgh, Rutgers, The State University of New Jersey, Army Medical University, Ealing Hospital, Southwest Hospital, Ealing Hospital NHS Trust, Imperial College London, Johns Hopkins University, Johns Hopkins Medicine, University Hospital of Geneva, Statens Serum Institut, Washington University in St. Louis, Environmental and Occupational Health Sciences Institute, Fred Hutch Cancer Center, Queen Mary University of London, William Harvey Research Institute, Heidelberg University, University Hospital Heidelberg, University Medical Centre Mannheim, John Radcliffe Hospital, Finnish Institute for Health and Welfare, University of Hawaiʻi at Mānoa, University of Hawaii System, Cancer Center of Hawaii, University of Hawaii Cancer Center, Icahn School of Medicine at Mount Sinai, King's College London, Universität Ulm, University Hospital Ulm, QIMR Berghofer Medical Research Institute, Child Health and Development Institute, National Institute on Aging, Institut für Medizinische Informatik, Biometrie und Epidemiologie, University of Dundee, Lund University, Ninewells Hospital, Skåne University Hospital, Umeå University, University of Eastern Finland, Hammersmith Hospital, Oxford Centre for Diabetes, Endocrinology and Metabolism, Universitätsmedizin Greifswald, University Medical Center Utrecht, Institute for Atherosclerosis Research, Tokyo Medical and Dental University, RIKEN Center for Integrative Medical Sciences, Centre National de la Recherche Scientifique, Université de Lille, European Genomic Institute for Diabetes, Netherlands Heart Institute, Helmholtz Zentrum München, Science Applications International Corporation (United States), Pathwest Laboratory Medicine, NHS Blood and Transplant, Centre for Medical Systems Biology, Azienda Sanitaria di Firenze, Dalarna University, University of San Carlos, Texas Biomedical Research Institute, IFB Adiposity Diseases, Leipzig University, Queensland University of Technology, National Human Genome Research Institute, Uppsala University Hospital, Department of Medical Sciences, Norwegian University of Science and Technology, University of California, Los Angeles, Los Angeles Biomedical Research Institute, Harokopio University of Athens, Institute for Molecular Medicine Finland, Massachusetts General Hospital, Kaiser Permanente, University of Leicester, Glenfield Hospital, NIHR Leicester Cardiovascular Biomedical Research Unit, German Center for Neurodegenerative Diseases, Kaiser Permanente Oakland Medical Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, University Hospital Regensburg, UC-Institut inter Régional pour la SAnté, Deutsches Diabetes-Zentrum e.V., German Center for Diabetes Research, Heinrich Heine University Düsseldorf, Western General Hospital, Institute of Genetics and Cancer, Boston University, National Heart Lung and Blood Institute, Framingham Heart Study, German Centre for Cardiovascular Research, Vrije Universiteit Amsterdam, Academic Center for Dentistry Amsterdam, Amsterdam University of Applied Sciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, Deutsches Herzzentrum München, Technical University of Munich, West Australian Sleep Disorders Research Institute, University of Helsinki, Finnish Institute of Occupational Health, Innsbruck Medical University, Helsinki Institute of Physics, Technische Hochschule Ulm, Montreal Heart Institute, University of Bristol, Institute of Genetic and Biomedical Research, Farr Institute, University College London, Amgen (United States), Sir Charles Gairdner Hospital, University of Bonn, Institute of Human Genetics, Life & Brain (Germany), Zimmer Biomet (Netherlands), Medical University of Graz, Ludwig-Maximilians-Universität München, Amsterdam Public Health, Universität Greifswald, University of Southern California, University of Iceland, Icelandic Heart Association, Royal College of Surgeons in Ireland, deCODE Genetics (Iceland), Loyola University Chicago, University of Chicago, University of Gothenburg, Erasmus University Rotterdam, Radboud University Nijmegen, Radboud University Medical Center, GlaxoSmithKline (United States), Institute for Integrative and Experimental Genomics, University of Lübeck, UiT The Arctic University of Norway, GlaxoSmithKline (United Kingdom), MRC Unit for Lifelong Health and Ageing, University College Dublin, Seoul National University, McGill University, Columbia University, The University of Melbourne, Shanghai Jiao Tong University, Shanghai Institute of Hematology, Department of Primary Industries and Regional Development, Department of Primary Industries and Regions South Australia, Korea National Institute of Health, Oxford BioMedica (United Kingdom), Howard Hughes Medical Institute, Yale University, Queen's University Belfast, Cancer Research And Biostatistics, Dalian Maritime University, Mary Lyon Centre at MRC Harwell, Agency for Science, Technology and Research, University of Massachusetts Boston, Genome Institute of Singapore, Helsinki University Hospital, Folkhälsans Forskningscentrum, Aalto University, Vanderbilt Health, Université de Strasbourg, Vanderbilt University Medical Center, Cedars-Sinai Medical Center, Ministry of Health, University of Milano-Bicocca, Vanderbilt University, Center for Human Genetics, University of Milan, Fondazione Filarete, University of Glasgow, West German Heart and Vascular Center Essen, University of Pisa, Czech Academy of Sciences, Institute of Physiology, Hôpital Rangueil, University of the West Indies, NorthShore University HealthSystem, University of Leeds, Eurac Research, Leeds Beckett University, Amsterdam UMC Location University of Amsterdam, Institute for Biomedicine, University of Utah, University of South Australia, South Australian Health and Medical Research Institute, University of Oulu, Institute of Child Health, Medizinische Hochschule Hannover, Oulu University Hospital, Public Health England, Oulu University of Applied Sciences, University of Essex, Imperial College Healthcare NHS Trust, Kuopio University Hospital, Tampere University, Fimlab (Finland), Steno Diabetes Centers, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, University of Washington, University of Liverpool, University of Iowa, Illumina (United Kingdom), University of Turku, Turku University Hospital, Pennington Biomedical Research Center, Ospedale di Bolzano, Pennsylvania State University, University of Split, South Karelia Central Hospital, Université de Montréal, University of Maryland, Baltimore, Center for Genomic Science, Paul Langerhans Institute Dresden, Greater Baltimore Medical Center, Inserm, Université Paris Cité, Sorbonne Université, Paris Cardiovascular Research Center, Fondation pour l’innovation en Cadiométabolisme et Nutrition, Centro Cardiologico Monzino, Institut Pasteur de Lille, Stanford University, Nanyang Technological University, The University of Texas Health Science Center at Houston, Utrecht University, Albert Einstein College of Medicine, Wake Forest University, Synlab Czech (Czechia), Synlab (Germany), Finnish Diabetes Association, Pirkanmaa Hospital District, Center for Non-Communicable Diseases, University of Pennsylvania, Universität für Weiterbildung Krems, King Abdulaziz University, Hospital La Paz Institute for Health Research, Newcastle University, LMU Klinikum, St George's, University of London, Oxford University Hospitals NHS Trust, Jena University Hospital, Addenbrooke's Hospital, Wellcome/MRC Institute of Metabolic Science

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