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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle, The European Alzheimer’s Disease Initiative (EADI),, Benjamin Grenier‐Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie‐Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R. Martin, Kristel Sleegers, Nandini Badarinarayan, Jóhanna Jakobsdóttir, Kara L. Hamilton‐Nelson, Sonia Moreno–Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N. Vardarajan, Jacques Epelbaum, Per Hoffmann, Merçé Boada, Gary W. Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L. Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V. Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C. Fox, Seung‐Hoan Choi, Ignacio Mateo, Joseph T. Hughes, Hieab H.H. Adams, John Malamon, Florentino Sánchez-García, Yogen Patel, Jennifer A. Brody, Beth A. Dombroski, María Cándida Déniz Naranjo, Makrina Daniilidou, Guðný Eiríksdóttir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B. Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloé Sarnowski, William S. Bush, Stéphane Meslage, Johannes Kornhuber, Charles C. White, Yeunjoo E. Song, Robert C. Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M. Adams, Rik Vandenberghe, Manuel Mayhaus, L. Adrienne Cupples, Marilyn S. Albert, Peter Paul De Deyn, Wei Gu, J.J. Himali, Duane Beekly, Alessio Squassina, Annette M. Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodríguez‐Rodríguez, Simon Lovestone, Melissa E. Garcia, Rachelle S. Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas Fairchild, Yolanda A. Benito, Clive Holmes, Hata Karamujić‐Čomić, Matthew P. Frosch, Håkan Thonberg, Wolfgang Maier, Gennady V. Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M. Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J. Katz, Letizia Concari, Jenny Lord, Alexa S. Beiser, C. Dirk Keene, Seppo Helisalmi, Iwona Kłoszewska, Walter A. Kukull, Anne M. Koivisto, Aoibhinn Lynch, Lluís Tárraga, Eric B. Larson, Annakaisa Haapasalo, Brian Lawlor, Sonia Thomas, Richard B. Lipton, Vincenzo Solfrizzi, Michael Gill, W. T. Longstreth, Thomas J. Montine, Vincenza Frisardi, Mónica Díez-Fairén, Fernando Rivadeneira, Ronald C. Petersen, Vincent Deramecourt, Ignacio Álvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M. Reiman, Nathalie Fiévet, Jerome I. Rotter, Joan Reisch, Olivier Hanon, Chiara Cupidi, André G. Uitterlinden, Donald R. Royall, Carole Dufouil, Raffaele Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George‐Hyslop, Karen Ritchie, Magda Tsolaki, Debby W. Tsuang, Bruno Dubois, David Craig, Chuang‐Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L. Albin, Laura Fratiglioni, Antonia Germanou, Liana G. Apostolova, Lina Keller, Maria Koutroumani, Steven E. Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice L. Whitehead, Craig Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ãngel Carracedo, Lars Lannfelt, David C. Rubinsztein, Lisa L. Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G. Beach, Janet Johnston, James T. Becker, Peter Passmore, Eileen H. Bigio, Jonathan M. Schott, Thomas D. Bird, Jason D. Warren, Bradley F. Boeve, Michelle K. Lupton, James D. Bowen, Petroula Proitsi, Adam Boxer, John Powell, James R. Burke, John S.K. Kauwe, Jeffrey M. Burns, Michelangelo Mancuso, Joseph D. Buxbaum, Ubaldo Bonuccelli, Nigel J. Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris Carlson, Nicholas Bass, Cynthia M. Carlsson, John Hardy, Regina M. Carney, José Brás, Minerva M. Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C. Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R. Graff‐Radford, Denis A. Evans, Angela Hodges, Kelley M. Faber, Martin Scherer, Kenneth B. Fallon, Markus J. Riemenschneider, David W. Fardo, Reinhard Heun, Martin R. Farlow, Heike Kölsch, Steven H. Ferris, Markus Leber, Tatiana Foroud, Isabella Heuser, Douglas Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H. Geschwind, John R. Gilbert, John C. Morris, Robert C. Green, Kevin H. Mayo, John H. Growdon, Thomas Feulner, Ronald L. Hamilton, Lindy E. Harrell, Dmitriy Drichel, Lawrence S. Honig, Thomas D. Cushion, Matthew J. Huentelman, Paul Hollingworth, Christine M. Hulette, Bradley T. Hyman, Iain Marshall, Gail P. Jarvik, Alun Meggy, Erin L. Abner, Georgina Menzies, Lee‐Way Jin, Ganna Leonenko, Luís Miguel Real, Gyungah R Jun, Clinton T. Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jonathan Kaye, Ronald Kim, Frank Jessen, Neil W. Kowall, Bruno Vellas, Joel H. Kramer, Emma Vardy, Frank M. LaFerla, Karl‐Heinz Jöckel, James J. Lah, Martin Dichgans, James B. Leverenz, David Mann, Allan I. Levey, Stuart Pickering‐Brown, Andrew P. Lieberman, Norman Klopp, Kathryn L. Lunetta, H.‐Erich Wichmann, Constantine G. Lyketsos, Kevin Morgan, Daniel Marson, Kristelle Brown, Frank Martiniuk, Christopher Medway, Deborah C. Mash, Markus M. Nöthen, Eliezer Masliah, Nigel M. Hooper, Wayne C. McCormick, Antonio Daniele, Susan M. McCurry, Antony Bayer, Andrew McDavid, John Gallacher, Ann C. McKee, Hendrik van den Bussche, Marsel Mesulam, Carol Brayne, Bruce L. Miller, Steffi G. Riedel‐Heller, Carol A. Miller, Joshua W. Miller, Ammar Al‐Chalabi, John C. Morris, Christopher E. Shaw, Amanda Myers, Jens Wiltfang, Sid E. O’Bryant, John Olichney, Victoria Álvarez, Joseph E. Parisi, Andrew B. Singleton, Henry L. Paulson, John Collinge, William Perry, Simon Mead, Elaine R. Peskind, David H. Cribbs, Martin N. Rossor, Aimee Pierce, Natalie S. Ryan, Wayne W. Poon, Benedetta Nacmias, Huntington Potter, Sandro Sorbi, Joseph F. Quinn, Eleonora Sacchinelli, Ashok Raj, Gianfranco Spalletta, Murray A. Raskind, Carlo Caltagirone, Paola Bossù, Maria Donata Orfei, ‌Barry Reisberg, Robert Clarke, Christiane Reitz, A. David Smith, John M. Ringman, Donald Warden, Erik D. Roberson, Gordon Wilcock, Ekaterina Rogaeva, Amalia C. Bruni, Howard J. Rosen, Maura Gallo, Roger N. Rosenberg, Yoav Ben‐Shlomo, Mark A. Sager, Patrizia Mecocci, Andrew J. Saykin, Pau Pástor, Michael L. Cuccaro, Jeffery M. Vance, Julie A. Schneider, Lori S. Schneider, Susan Slifer, William W. Seeley, Amanda Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Russell H. Swerdlow, Mitchell Tang, Rudolph E. Tanzi, John Q. Trojanowski, Juan C. Troncoso, Vivianna M. Van Deerlin, Linda J. Van Eldik, Harry V. Vinters, Jean Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Kirk C. Wilhelmsen, Jennifer Williamson, Thomas S. Wingo, Randall L. Woltjer, Clinton B. Wright, Chang‐En Yu, Lei Yu, Yasaman Saba, Alberto Pilotto, María J. Bullido, Oliver Peters, Paul K. Crane, David A. Bennett, Paola Bosco, Eliécer Coto, Virginia Boccardi, Phil L. De Jager, Alberto Lleó, Nicholas A. Warner, Lorna M. Lopez, Martin Ingelsson, Panos Deloukas, Carlos Cruchaga, Caroline Graff, Rhian Gwilliam, Myriam Fornage, Alison Goate, Pascual Sánchez‐Juan, Patrick G. Kehoe, Najaf Amin, N. Ertekin-Taner, Claudine Berr, Stéphanie Debette, Seth Love, Lenore J. Launer, Steven G. Younkin, Jean‐François Dartigues, Chris Corcoran, M. Arfan Ikram, Dennis W. Dickson, Gaël Nicolas, Dominique Campion, JoAnn T. Tschanz, Helena Schmidt, Håkon Håkonarson, Jordi Clarimón, Ron Munger, Reinhold Schmidt, Lindsay A. Farrer, Christine Van Broeckhoven, Michael O’Donovan, Anita L. DeStefano, Lesley Jones, Jonathan L. Haines, Jean-François Deleuze, Michael J. Owen, Vilmundur Guðnason, Richard Mayeux, Valentina Escott‐Price, Bruce M. Psaty, Alfredo Ramı́rez, Li-San Wang, Agustı́n Ruiz, Cornelia M. van Duijn, Peter Holmans, Sudha Seshadri, Julie Williams, Philippe Amouyel, Gerard D. Schellenberg, Jean‐Charles Lambert, Margaret A. Pericak‐Vance

Nature Genetics, 2019

University of Miami, Dr. John T. Macdonald Foundation, Inserm, Université de Lille, Institut Pasteur de Lille, Cardiff University, University of Washington, UK Dementia Research Institute, University of Pennsylvania, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Centre National de Recherche en Génomique Humaine, CEA Paris-Saclay, Erasmus MC, Boston University, VIB-UAntwerp Center for Molecular Neurology, University of Antwerp, Icelandic Heart Association, Fundació ACE, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red, University of Eastern Finland, Kuopio University Hospital, Columbia University, Université Paris Cité, University of Bonn, University of Basel, University Hospital of Basel, Life & Brain (Germany), Dublin City University, University College London, University of Michigan, University of Iceland, University of South Florida, John Radcliffe Hospital, University of Oxford, USF Health Byrd Alzheimer's Institute, Brown Foundation, University of Cagliari, Universidad de Cantabria, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla, King's College London, Hospital Universitario de Gran Canaria Doctor Negrín, Aristotle University of Thessaloniki, Normandie Université, Université de Rouen Normandie, MRC Prion Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Medical University of Graz, Ferrari (Italy), Case Western Reserve University, Friedrich-Alexander-Universität Erlangen-Nürnberg, Broad Institute, University of North Texas, University of North Texas Health Science Center, Saarland University, The University of Texas Southwestern Medical Center, KU Leuven, Johns Hopkins University, Martin Luther University Halle-Wittenberg, Harvard University, Massachusetts General Hospital, National Institute on Aging, Baylor College of Medicine, University of Southampton, Karolinska University Hospital, German Center for Neurodegenerative Diseases, Karolinska Institutet, Indiana University – Purdue University Indianapolis, Uppsala University, University Hospital Bonn, University of Duisburg-Essen, University of Pittsburgh, University of Nottingham, Queen's Medical Centre, Albert Einstein College of Medicine, University of Parma, Fondazione Europea Ricerca Biomedica, Medical University of Lodz, Trinity College Dublin, St. James's Hospital, Kaiser Permanente Washington Health Research Institute, University of Mississippi Medical Center, University of Bari Aldo Moro, University Hospital Mútua de Terrassa, Mútua Terrassa, Fundació Clínic per a la Recerca Biomèdica, Mayo Clinic in Arizona, Netherlands Consortium for Healthy Ageing, Centre Hospitalier Universitaire de Lille, Fondazione Santa Lucia, The University of Texas Health Science Center at Houston, Translational Genomics Research Institute, Alzheimer's Association, University of Arizona, University of Phoenix, Banner Alzheimer’s Institute, Arizona Alzheimer’s Consortium, The Lundquist Institute, Harbor–UCLA Medical Center, Assistance Publique – Hôpitaux de Paris, Hôpital Broca, Veterans Health Administration, Geriatric Research Education and Clinical Center, Université de Bordeaux, Centre Hospitalier Universitaire de Bordeaux, Icahn School of Medicine at Mount Sinai, Centre National de la Recherche Scientifique, Sorbonne Université, Institut du Cerveau, University of Perugia, Pitié-Salpêtrière Hospital, University of Cambridge, University of Toronto, Neuropsychiatrie : Recherche Epidemiologique et Clinique, Occupational Cancer Research Centre, Université de Montpellier, University of Edinburgh, VA Puget Sound Health Care System, Queen's University Belfast, Texas Tech University, Texas Tech University Health Sciences Center, Stockholm University, VA Ann Arbor Healthcare System, Indiana University School of Medicine, University of Wisconsin–Madison, AXA Research Fund, Universidade de Santiago de Compostela, Centre for Biomedical Network Research on Rare Diseases, Institut des Maladies Génétiques Imagine, Alzheimer Precision Medicine, Rush University Medical Center, Heidelberg University, University Hospital Heidelberg, Central Institute of Mental Health, Banner Sun Health Research Institute, Northwestern University, QIMR Berghofer Medical Research Institute, Swedish Medical Center, University of California, San Francisco, Duke University, Brigham Young University, University of Kansas Medical Center, University of Pisa, Washington University in St. Louis, Fred Hutch Cancer Center, Bruce W. Carter VA Medical Center, Mayo Clinic in Florida, University of Southern California, Università Cattolica del Sacro Cuore, University of California, Davis, University of California, Irvine, Mount Sinai Medical Center, Universität Hamburg, University Medical Center Hamburg-Eppendorf, University of Alabama at Birmingham, University of Kentucky, New York University, University of Cologne, Charité - Universitätsmedizin Berlin, University of California San Diego, Emory University, Emory Healthcare, University of Freiburg, University of California, Los Angeles, Brigham and Women's Hospital, University of Washington Medical Center, Hospital Universitario de Valme, University of Zurich, Oregon Health & Science University, Portland VA Medical Center, Université Fédérale de Toulouse Midi-Pyrénées, Newcastle Hospitals - Campus for Ageing and Vitality, Newcastle University, LMU Klinikum, Cleveland Clinic, Lou Ruvo Brain Institute, Manchester Academic Health Science Centre, University of Manchester, Helmholtz Zentrum München, BioBank Japan, Ludwig-Maximilians-Universität München, University Hospital of Wales, Leipzig University, University of Aveiro, Hospital Universitario Central de Asturias, National Institutes of Health, University of Florence, University of Colorado Denver, Don Carlo Gnocchi Foundation, Istituti di Ricovero e Cura a Carattere Scientifico, University of Bristol, University of North Carolina at Chapel Hill, National Institute of Neurological Disorders and Stroke, Casa Sollievo della Sofferenza, Ente Ospedaliero Ospedali Galliera, Hospital La Paz Institute for Health Research, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Oasi Maria SS, Columbia University Irving Medical Center, Hospital de Sant Pau, Somerset Partnership NHS Foundation Trust, Wellcome Sanger Institute, Southmead Hospital, WinnMed, Utah State University, Centre Hospitalier du Rouvray, Children's Hospital of Philadelphia, Institute for Neurodegenerative Disorders

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