Publication & Citation Trends
Most Cited Works
Publications
62 total
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease PDF
Cited by 438
OpenAlex
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors PDF
Cited by 77
OpenAlex
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality PDF
Cited by 43
OpenAlex
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors PDF
Cited by 78
OpenAlex
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design PDF
Cited by 46
OpenAlex
Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice
Cited by 57
OpenAlex
Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor PDF
Cited by 433
OpenAlex
Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice
Cited by 83
OpenAlex
Research Topics
Alzheimer's disease research and treatments
(28)
Cholinesterase and Neurodegenerative Diseases
(18)
Computational Drug Discovery Methods
(11)
Crystallization and Solubility Studies
(9)
X-ray Diffraction in Crystallography
(9)
Frequent Co-Authors
Affiliations
Merck & Co., Inc., Rahway, NJ, USA (United States)
University of Alberta
Pfizer (United States)
Princeton University
AVEO Oncology (United States)