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AC

Amanda X. Y. Chen

The University of Melbourne AU

15
Publications
1,687
Citations
10
H-Index
10
i10-Index
49.4
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex . OA = OpenAlex S2 = Semantic Scholar
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Publication & Citation Trends

Most Cited Works

Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade
Imran G. House, Peter Savas, Junyun Lai, Amanda X. Y. Chen, Amanda J. Oliver +15 more
Clinical Cancer Research 2019
720
Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity
Junyun Lai, Sherly Mardiana, Imran G. House, Kevin Sek, Melissa A. Henderson +15 more
Nature Immunology 2020
209
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy OA
Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Junyun Lai, Amanda X. Y. Chen +14 more
Nature Communications 2021
202
FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy OA
Jack D. Chan, C. Scheffler, Isabelle Munoz, Kevin Sek, Joel N. Lee +33 more
Nature 2024
196
IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors OA
Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Imran G. House, Junyun Lai +15 more
Molecular Therapy 2020
103

Publications

15 total

Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery PDF

Amanda X. Y. Chen, Kah Min Yap, Joelle S. Kim, Kevin Sek, Yukuan Huang et al. - Nature, 2025
Cited by 41 OpenAlex

Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors PDF

Kevin Sek, Amanda X. Y. Chen, Thomas Cole, Jesse Armitage, Junming Tong et al. - Nature Communications, 2025
Cited by 7 OpenAlex

Abstract LT01: Identifying Optimal Tumour-specific Promoters for CRISPR/Cas9 Engineering of Armoured CAR T Cells with Enhanced Safety and Efficacy

Kah Min Yap, Amanda X. Y. Chen, Imran G. House, Phillip K. Darcy, Paul A. Beavis - Cancer Research, 2025
Cited by 0 OpenAlex

FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy PDF

Jack D. Chan, C. Scheffler, Isabelle Munoz, Kevin Sek, Joel N. Lee et al. - Nature, 2024
Cited by 196 OpenAlex

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity PDF

Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X. Y. Chen, Jasmine Li et al. - Cell Reports, 2024
Cited by 3 OpenAlex

CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity PDF

Imran G. House, Emily B. Derrick, Kevin Sek, Amanda X. Y. Chen, Jasmine Li et al. - Cell Reports, 2023
Cited by 10 OpenAlex

A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses PDF

Kirsten L. Todd, Junyun Lai, Kevin Sek, Yukuan Huang, Dane M. Newman et al. - Nature Communications, 2023
Cited by 7 OpenAlex

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy PDF

Lauren Giuffrida, Kevin Sek, Melissa A. Henderson, Junyun Lai, Amanda X. Y. Chen et al. - Nature Communications, 2021
Cited by 202 OpenAlex

MAIT cells regulate NK cell-mediated tumor immunity PDF

Emma V. Petley, Hui‐Fern Koay, Melissa A. Henderson, Kevin Sek, Kirsten L. Todd et al. - Nature Communications, 2021
Cited by 94 OpenAlex

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

Junyun Lai, Sherly Mardiana, Imran G. House, Kevin Sek, Melissa A. Henderson et al. - Nature Immunology, 2020
Cited by 209 OpenAlex

Research Topics

CAR-T cell therapy research (10) Immune Cell Function and Interaction (8) CRISPR and Genetic Engineering (5) Viral Infectious Diseases and Gene Expression in Insects (4) Immunotherapy and Immune Responses (3)

Frequent Co-Authors

IM
Imran G. House
14 joint publications
PA
Paul A. Beavis
14 joint publications
PH
Phillip K. Darcy
13 joint publications
JU
Junyun Lai
11 joint publications
KI
Kirsten L. Todd
11 joint publications
KE
Kevin Sek
11 joint publications

Affiliations

University of Sydney
AU 2016 - 2016
The University of Melbourne
AU 2025 - 2019
Peter MacCallum Cancer Centre
AU 2025 - 2019

External Profiles

OpenAlex Profile Search Semantic Scholar Google Scholar

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