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GH

Gregory Hook

American Life Science Pharmaceuticals (United States) US

28

Publications

1,502

Citations

18

H-Index

19

i10-Index

0

2yr Mean Cite

-

Cite/Paper

Data combined from OpenAlex . OA = OpenAlex S2 = Semantic Scholar

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Publication & Citation Trends

Most Cited Works

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein OA

Vivian Hook, Mark S. Kindy, Gregory Hook

Journal of Biological Chemistry 2008

204

Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease

Vivian Hook, Thomas Toneff, Matthew Bogyo, Doron C. Greenbaum, Katalin F. Medzihradszky +4 more

Biological Chemistry 2005

168

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Vivian Hook, Michael C. Yoon, Charles Mosier, Gen Ito, Sonia Podvin +4 more

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2020

167

The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity OA

Gregory Hook, Vivian Hook, Mark S. Kindy

Journal of Alzheimer s Disease 2011

110

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Vivian Hook, Mark S. Kindy, Thomas Reinheckel, Christoph Peters, Gregory Hook

Biochemical and Biophysical Research Communications 2009

107

Publications

28 total

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders PDF

Gregory Hook, Thomas Reinheckel, Junjun Ni, Zhou Wu, Mark S. Kindy et al. - Pharmacological Reviews, 2022

Cited by 93 OpenAlex

Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B PDF

Michael C. Yoon, Mitchell P. Christy, Von V. Phan, William H. Gerwick, Gregory Hook et al. - Biochemistry, 2022

Cited by 41 OpenAlex

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions PDF

Michael C. Yoon, Angelo Solania, Zhenze Jiang, Mitchell P. Christy, Sonia Podvin et al. - ACS Chemical Biology, 2021

Cited by 55 OpenAlex

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

Vivian Hook, Michael C. Yoon, Charles Mosier, Gen Ito, Sonia Podvin et al. - Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020

Cited by 167 OpenAlex

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate PDF

Gregory Hook, J. Steven Jacobsen, Kenneth H. Grabstein, Mark S. Kindy, Vivian Hook - Frontiers in Neurology, 2015

Cited by 102 OpenAlex

Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic

Gregory Hook, Jin Yu, Thomas Toneff, Mark S. Kindy, Vivian Hook - Journal of Alzheimer s Disease, 2014

Cited by 83 OpenAlex

The Cysteine Protease Inhibitor, E64d, Reduces Brain Amyloid-β and Improves Memory Deficits in Alzheimer's Disease Animal Models by Inhibiting Cathepsin B, but not BACE1, β-Secretase Activity PDF

Gregory Hook, Vivian Hook, Mark S. Kindy - Journal of Alzheimer s Disease, 2011

Cited by 110 OpenAlex

Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease

Vivian Hook, Lydiane Funkelstein, Jill Wegrzyn, Steven J. Bark, Mark S. Kindy et al. - Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011

Cited by 67 OpenAlex

Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease

Vivian Hook, Gregory Hook, Mark S. Kindy - Biological Chemistry, 2010

Cited by 47 OpenAlex

Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein

Vivian Hook, Mark S. Kindy, Thomas Reinheckel, Christoph Peters, Gregory Hook - Biochemical and Biophysical Research Communications, 2009

Cited by 107 OpenAlex

Research Topics

Alzheimer's disease research and treatments (19) Trace Elements in Health (7) S100 Proteins and Annexins (7) Protease and Inhibitor Mechanisms (5) Cellular transport and secretion (4)

Frequent Co-Authors

VI

Vivian Hook

15 joint publications

MA

Mark S. Kindy

10 joint publications

MI

Michael C. Yoon

3 joint publications

AN

Anthony J. O’Donoghue

3 joint publications

TH

Thomas Toneff

2 joint publications

CH

Charles Mosier

2 joint publications

Affiliations

National Institutes of Health

US 1988 - 1988

University of Freiburg

DE 2022 - 2022

Heidelberg University

DE 2022 - 2022

American Life Science Pharmaceuticals (United States)

US 2023 - 2005

National Institute of Neurological Disorders and Stroke

US 1988 - 1988

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