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Weiming Xia

Boston University US

ORCID iD 0000-0002-7463-3295
266
Publications
17,194
Citations
57
H-Index
144
i10-Index
2.71
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex . OA = OpenAlex S2 = Semantic Scholar
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Publication & Citation Trends

Most Cited Works

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity
Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski, Thekla S. Diehl, W. Taylor Kimberly +1 more
Nature 1999
1,920
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
Martin Citron, David Westaway, Weiming Xia, George A. Carlson, Thekla S. Diehl +18 more
Nature Medicine 1997
1,265
Skeletal and CNS Defects in Presenilin-1-Deficient Mice OA
Jie Shen, Roderick T. Bronson, Dongfeng Chen, Weiming Xia, Dennis J. Selkoe +1 more
Cell 1997
956
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
Li-Bang Yang, Kristina Lindholm, Riqiang Yan, Martin Citron, Weiming Xia +7 more
Nature Medicine 2003
725
Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration OA
Ahmad Salehi, Jean‐Dominique Delcroix, Pavel V. Belichenko, Ke Zhan, Chengbiao Wu +15 more
Neuron 2006
546

Publications

262 total

Beta-amyloid deposition in chronic traumatic encephalopathy PDF

Thor D. Stein, Philip H. Montenigro, Victor E. Alvarez, Weiming Xia, John F. Crary et al. - Acta Neuropathologica, 2015
Cited by 288 OpenAlex

Increased App Expression in a Mouse Model of Down's Syndrome Disrupts NGF Transport and Causes Cholinergic Neuron Degeneration PDF

Ahmad Salehi, Jean‐Dominique Delcroix, Pavel V. Belichenko, Ke Zhan, Chengbiao Wu et al. - Neuron, 2006
Cited by 546 OpenAlex

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Lucia Pastorino, Anyang Sun, Pei‐Jung Lu, Xiao Zhen Zhou, Martin Balaštík et al. - Nature, 2006
Cited by 492 OpenAlex

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Li-Bang Yang, Kristina Lindholm, Riqiang Yan, Martin Citron, Weiming Xia et al. - Nature Medicine, 2003
Cited by 725 OpenAlex

APP processing is regulated by cytoplasmic phosphorylation PDF

Ming-Sum Lee, Shih-Chu Kao, Cynthia A. Lemere, Weiming Xia, Huang-Chun Tseng et al. - The Journal of Cell Biology, 2003
Cited by 437 OpenAlex

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski, Thekla S. Diehl, Chad L. Moore et al. - Nature Cell Biology, 2000
Cited by 518 OpenAlex

Presenilin-Mediated Modulation of Capacitative Calcium Entry PDF

Andrew S. Yoo, Isaac T Cheng, Sungkwon Chung, Tallessyn Z. Grenfell, Hanmi Lee et al. - Neuron, 2000
Cited by 313 OpenAlex

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski, Thekla S. Diehl, W. Taylor Kimberly et al. - Nature, 1999
Cited by 1,920 OpenAlex

Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42 PDF

Ruth G. Perez, Salvador Soriano, Jay D. Hayes, Beth L. Ostaszewski, Weiming Xia et al. - Journal of Biological Chemistry, 1999
Cited by 384 OpenAlex

Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease

Michael S. Wolfe, Weiming Xia, Chad L. Moore, Dartha D. Leatherwood, Beth L. Ostaszewski et al. - Biochemistry, 1999
Cited by 288 OpenAlex

Research Topics

Alzheimer's disease research and treatments (150) Dementia and Cognitive Impairment Research (38) Cholinesterase and Neurodegenerative Diseases (33) Computational Drug Discovery Methods (19) Prion Diseases and Protein Misfolding (18)

Frequent Co-Authors

DE
Dennis J. Selkoe
6 joint publications
BE
Beth L. Ostaszewski
4 joint publications
TH
Thekla S. Diehl
4 joint publications
MA
Martin Citron
4 joint publications
ED
Edward H. Koo
3 joint publications
MI
Michael S. Wolfe
2 joint publications

Affiliations

University College Dublin
IE 2009 - 2009
Boston University
US 2025 - 2016
National Academy of Medicine
US 2006 - 2006
Brigham and Women's Hospital
US 2012 - 1997
Houston Methodist
US 2020 - 1999

External Profiles

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