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JS

Joseph R. Stock

Novo Nordisk (United States) US

33
Publications
835
Citations
17
H-Index
19
i10-Index
1.0
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex . OA = OpenAlex S2 = Semantic Scholar
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Publication & Citation Trends

Most Cited Works

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease OA
Scott C. Mayer, Anthony F. Kreft, Boyd L. Harrison, Magid Abou‐Gharbia, Madelene Antane +41 more
Journal of Medicinal Chemistry 2008
109
Acylguanidines as Small-Molecule β-Secretase Inhibitors OA
Derek C. Cole, Eric S. Manas, Joseph R. Stock, Jeffrey S. Condon, Lee D. Jennings +21 more
Journal of Medicinal Chemistry 2006
100
Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism OA
L. Nathan Tumey, Carolyn A. Leverett, Beth C. Vetelino, Fengping Li, Brian Rago +20 more
ACS Medicinal Chemistry Letters 2016
70
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets OA
Derek C. Cole, Joseph R. Stock, Rajiv Chopra, Rebecca Cowling, John W. Ellingboe +17 more
Bioorganic & Medicinal Chemistry Letters 2007
70
Discovery of N<sub>1</sub>-(6-Chloroimidazo[2,1-<i>b</i>][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT<sub>6</sub>Receptor Agonist OA
Derek C. Cole, Joseph R. Stock, William J. Lennox, Ronald C. Bernotas, John W. Ellingboe +14 more
Journal of Medicinal Chemistry 2007
58

Publications

33 total

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism PDF

L. Nathan Tumey, Carolyn A. Leverett, Beth C. Vetelino, Fengping Li, Brian Rago et al. - ACS Medicinal Chemistry Letters, 2016
Cited by 70 OpenAlex

Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads

Carolyn A. Leverett, Sai Chetan K. Sukuru, Beth C. Vetelino, Sylvia Musto, Kevin Parris et al. - ACS Medicinal Chemistry Letters, 2016
Cited by 38 OpenAlex

A fluorescent assay suitable for inhibitor screening and vanin tissue quantification

Benfang Helen Ruan, Derek C. Cole, Paul W. Wu, Amira Quazi, Karen Page et al. - Analytical Biochemistry, 2009
Cited by 47 OpenAlex

Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors PDF

Paweł Nowak, Derek C. Cole, Ann Aulabaugh, Jonathan Bard, Rajiv Chopra et al. - Bioorganic & Medicinal Chemistry Letters, 2009
Cited by 27 OpenAlex

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease PDF

Scott C. Mayer, Anthony F. Kreft, Boyd L. Harrison, Magid Abou‐Gharbia, Madelene Antane et al. - Journal of Medicinal Chemistry, 2008
Cited by 109 OpenAlex

Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCθ) Inhibitors PDF

Derek C. Cole, Magda Asselin, Agnes Brennan, Robert Czerwiński, John W. Ellingboe et al. - Journal of Medicinal Chemistry, 2008
Cited by 45 OpenAlex

Discovery of a novel series of Notch-sparing γ-secretase inhibitors PDF

Anthony F. Kreft, Boyd L. Harrison, Suzan Aschmies, Kevin Atchison, David S. Casebier et al. - Bioorganic & Medicinal Chemistry Letters, 2008
Cited by 25 OpenAlex

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets PDF

Derek C. Cole, Joseph R. Stock, Rajiv Chopra, Rebecca Cowling, John W. Ellingboe et al. - Bioorganic & Medicinal Chemistry Letters, 2007
Cited by 70 OpenAlex

Discovery of N<sub>1</sub>-(6-Chloroimidazo[2,1-<i>b</i>][1,3]thiazole-5-sulfonyl)tryptamine as a Potent, Selective, and Orally Active 5-HT<sub>6</sub>Receptor Agonist PDF

Derek C. Cole, Joseph R. Stock, William J. Lennox, Ronald C. Bernotas, John W. Ellingboe et al. - Journal of Medicinal Chemistry, 2007
Cited by 58 OpenAlex

Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si2.gif" overflow="scroll"><mml:mrow><mml:msubsup><mml:mrow><mml:mi mathvariant="bold">S</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn></mml:mrow><mml:mrow><mml:mo>′</mml:mo></mml:mrow></mml:msubsup></mml:mrow></mml:math> substrate binding pocket

Lee D. Jennings, Derek C. Cole, Joseph R. Stock, Mohani N. Sukhdeo, John W. Ellingboe et al. - Bioorganic & Medicinal Chemistry Letters, 2007
Cited by 36 OpenAlex

Research Topics

Alzheimer's disease research and treatments (6) Computational Drug Discovery Methods (6) Chemical Synthesis and Analysis (6) Cholinesterase and Neurodegenerative Diseases (4) Pediatric Urology and Nephrology Studies (3)

Frequent Co-Authors

DE
Derek C. Cole
12 joint publications
JO
John W. Ellingboe
10 joint publications
BO
Boyd L. Harrison
5 joint publications
KR
Kristi Fan
5 joint publications
YU
Yun Hu
5 joint publications
ER
Erik Wagner
5 joint publications

Affiliations

NewYork–Presbyterian Hospital
US 1998 - 1996
Harvard University
US 1980 - 1980
Johns Hopkins University
US 2003 - 2003
Youngstown State University
US 1999 - 1998
Crozer-Keystone Health System
US 2003 - 1982

External Profiles

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